NOVEL AMINOINDAZOLE DERIVATIVES AS MEDICINAL AGENTS AND PHARMECEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES Russian patent published in 2010 - IPC C07D231/56 C07D403/12 C07D401/12 C07D409/12 C07D413/12 A61K31/416 A61K31/4427 A61K31/4523 A61K31/496 A61K31/497 

FIELD: chemistry.

SUBSTANCE: invention relates to formula compounds, as well as their pharmaceutically acceptable salts, a pharmaceutical composition based on them, with inhibitory activity towards phosphorylation of protein Tau, and to methods of producing said compounds. In formula (I), R5 is aryl, aryl(C₁-C₆)alkyl; R6 is halogen; R3 is (C₁-C₆)alkyl, possibly substituted with substitutes selected from halogen, OH, NH₂, azetidine; or monocyclic aryl or heteroaryl, such as thiophene or pyridine, possibly substituted with substitutes selected from NO₂, CN, (C₁-C₆)alkoxy, (C₁-C₆)alkyl; or CONR₁R₂, SO₂R^a, C(=NH)R1^b, COOR1^c; R1, R2 independently represent a hydrogen atom, possibly substituted with one halogen atom, (C₁-C₆)alkyl, moncyclic aryl or monocyclic 5- or 6-member heteroaryl containing 1 or 2 heteroatoms, such as S, O, N, possibly substituted with one or more substitutes selected from halogen, (C₁-C₆)alkyl, (C₁-C₆)alkoxyl, trifluoromethyl, N(CH₃)₂; or R1 and R2 can form a 5- or 6-member ring which optionally contains a heteroatom such as N; R1^a is aryl, possibly substituted with (C₁-C₆)alkoxy; R1^b is (C₁-C₆)alkyl, possibly substituted aryl or 6-member heteroaryl, containing 1 or 2 N atoms, where the substitute is (C₁-C₆)alkoxyl; R1^c is (C₁-C₆)alkyl, (C₂-C₆)alkenyl; and their pharmaceutically acceptable salts.

EFFECT: aminoindazole derivatives as kinase inhibitor.

8 cl, 44 ex