FIELD: organic chemistry, pharmacy.
SUBSTANCE: invention relates to a new form of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole known as the international non-patented name omeprazole. Invention relates to a new crystalline form of (S)-enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole potassium salt. Invention relates also to methods for preparing such form of (S)-omeprazole and pharmaceutical compositions comprising it. Indicated compound inhibits secretion of gastric acid and can be used in medicine for treatment of gastro-enteric disorders.
EFFECT: improved preparing method, valuable medicinal properties of drug.
8 cl, 2 dwg, 1 ex
Title |
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Number |
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