FIELD: organic chemistry, pharmacy.
SUBSTANCE: invention relates to a new form of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole known as the international non-patented name omeprazole. Invention relates to a new crystalline form of (S)-enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole potassium salt. Invention relates also to methods for preparing such form of (S)-omeprazole and pharmaceutical compositions comprising it. Indicated compound inhibits secretion of gastric acid and can be used in medicine for treatment of gastro-enteric disorders.
EFFECT: improved preparing method, valuable medicinal properties of drug.
8 cl, 2 dwg, 1 ex
| Title |
Year |
Author |
Number |
| S-OMEPRAZOLE MAGNESIUM SALT TRIHYDRATE, METHODS OF ITS PREPARING, INTERMEDIATE PRODUCT FOR ITS PREPARING, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND METHOD OF TREATMENT |
1998 |
- Kotton Khanna
- Kronstrem Anders
- Mattson Anders
- Meller Ehva
|
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| OPTICALLY PURE Na, Mg, Li, K OR Ca SALTS OF (-)-5-METHOXY-2-[[(4- -METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZ-IMIDAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON SAID AND INTERMEDIATE COMPOUND |
1994 |
- Per Lennart Lindberg
- Sverker Von Unge
|
RU2137766C1 |
| ALKOXY-SUBSTITUTED BENZIMIDAZOLE COMPOUNDS, PHARMACEUTICAL PREPARATIONS COMPRISING THEREOF AND METHOD FOR THEIR USING |
2000 |
- Uittl Robert R.
- Sanchilio Frederik D.
- Stouehll Grehjson Uoker
- Dzhenkins Duglas Dzhon
- Uittol Linda
- Mejer Glenn Alan
- Fontana Stiven A.
|
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| S-OMEPRASOL IN NEUTRAL FORM, METHODS OF ITS PREPARING, PHARMACEUTICAL COMPOSITION CONTAINING S-OMEPRASOL IN NEUTRAL FORM AND METHOD OF TREATMENT OF STATE ASSOCIATED WITH GASTRIC ACID |
1997 |
- Bokhlin Martin
- Khorvat Karol'
- Von Unge Sverker
|
RU2184734C2 |
| OMEPRAZOLE FORM A, METHOD FOR ITS PREPARING, PHARMACEUTICAL PREPARATION BASED ON THEREOF AND METHOD OF TREATMENT OF GASTROENTERIC DISTURBANCES |
1998 |
- Levkvist Karin
- Noreland David
- Sunden Gunnel'
- Imen Ingvar
|
RU2207339C2 |
| INCLUSION COMPLEX OF S-OMEPRAZOLE (ESOMEPRAZOLE) WITH CYCLODEXTRIN |
2002 |
- Khamid Jusuf Khuadzha
- Rao Dkharmaradzh Ramachandra
|
RU2313343C2 |
| METHOD FOR PREPARING OMEPRAZOLE |
1998 |
- Kotton Khanna
- Larsson Magnus
- Mattson Anders
|
RU2211218C2 |
| METHOD OF PREPARING MAGNESIUM SALT OF SUBSTITUTED SULFINYL-TETEROCYCLIC COMPOUND |
1997 |
- Khegberg Jan-Oke
- Ioannidis Panagiotis
- Mattson Anders
|
RU2163238C2 |
| OMEPRAZOL FORM B SODIUM SALT, METHOD OF ITS PREPARING (VERSIONS) AND PHARMACEUTICAL PREPARATION COMPRISING OMEPRAZOL FORM B SODIUM SALT |
1998 |
- Gustavsson Anders
- K'El'Bom Kristina
- Imen Ingvar
|
RU2186778C2 |
| OMEPRAZOLE FORM, METHODS FOR PRODUCTION AND USES THEREOF |
2002 |
- Khafner Milae Natasa
- Ehopar Anton
- Podovnik Barbara
- Sizerle Beleje Andreja
- Koshak Alenka
- Ornik Brina
- Urleb Uros
|
RU2286991C2 |
