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2 286 991

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(51)

IPC

C07D401/12(2006-01-01)

A61K31/4439(2006-01-01)

A61P1/04(2006-01-01)

(21) (22)

Application

2003133213/04, 2002-04-24

(24)

Start date

2002-04-24

(22)

Actual filing date

2002-04-24

(45)

Published

2006-11-10

(72)

Inventor

Khafner Milae NatasaEhopar AntonPodovnik BarbaraSizerle Beleje AndrejaKoshak AlenkaOrnik BrinaUrleb Uros

(73)

Holder

Lek Farmas'Jutikal Ehnd Kemikal Kompani D.D.

OMEPRAZOLE FORM, METHODS FOR PRODUCTION AND USES THEREOF Russian patent published in 2006 - IPC C07D401/12 A61K31/4439 A61P1/04

Abstract RU 2286991 C2

FIELD: organic chemical, pharmaceuticals.

SUBSTANCE: invention relates to new crystalline form of substance known as 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole (general name is omeprazole), titled in present description as C form omeprazole. Claimed omeprazole has the next pattern obtained by powdered X-ray diffraction:

valuesof dÅrelative intensity9.5-9.6very strong7.9-8.0strong7.4-7.5weer7.2very strong5.9-6.0medium5.6medium5.1-5.2very strong4.88-4.90weer4.81-4.84weer4.65-4.67medium4.57-4.60medium4.48-4.51strong4.34-4.36medium4.16-4.19weer3.94-3.97weer3.72-3.73strong3.58-3.59medium3.46-3.47strong3.29-3.30medium3.23-3.25strong3.19-3.20medium3.11-3.12weer3.03-3.04weer

Methods for production of C form omeprazole, pharmaceutical composition for treatment of gastrointestinal diseases, containing target product in combination with pharmaceutically acceptable excipients, and application of C form omeprazole in preparation of drug for treatment of gastrointestinal diseases also are described.

EFFECT: new drug for treatment of gastrointestinal diseases.

13 cl, 8 dwg, 3 tbl, 5 ex

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RU 2 286 991 C2

Authors

Khafner Milae Natasa

Ehopar Anton

Podovnik Barbara

Sizerle Beleje Andreja

Koshak Alenka

Ornik Brina

Urleb Uros

Dates

2006-11-10—Published

2002-04-24—Filed