INCLUSION COMPLEX OF S-OMEPRAZOLE (ESOMEPRAZOLE) WITH CYCLODEXTRIN Russian patent published in 2007 - IPC A61K31/4439 A61K31/724 A61P1/04 

FIELD: medicine, pharmacy.

SUBSTANCE: invention describes a stable inclusion complex comprising pure S-omeprazole and cyclodextrin wherein the mole ratio of S-omeprazole to cyclodextrin = from 1:1.5 to 1:5.Method for preparing this complex involves addition of cyclodextrin to S-omeprazole or its pharmacologically acceptable salt an aqueous-alkaline solution, dilution of mixture containing this complex and regulation of pH to value between 8 and 10 using boric acid aqueous solution or other equivalent agents at temperature of a solution/mixture maintaining at the level 30⁰C or above followed by cooling a mixture to 5⁰C or below and isolation of the prepared inclusion complex from a solution. The inclusion complex prepared by this method can be extracted easily as a stable white powder and this powder, in turn, shows advantage involving convenience handling.

EFFECT: improved preparing method, improved and valuable properties of complex.

7 cl, 4 ex