COMPOSITIONS AND METHODS FOR WT1-SPECIFIC IMMUNOTHERAPY Russian patent published in 2004 - IPC

FIELD: chemistry of proteins, biochemistry, medicine.

SUBSTANCE: invention describes a polypeptide representing the sequence disclosed in description taken among SEQ ID No.: 15-20, 28-312, 315 and 316. Polypeptide comprises immunogenic moiety of the natural WT1 determined by the sequence SEQ ID No.: 319, or its variant wherein from 1 to 3 amino acids in immunogenic moiety are replaced so that capacity of variant to interact with WT1-specific antisera and/or T-cellular lines or clones is reduced significantly. Polypeptide comprises a sequence consisting of 16 amino acid residues following one after another, not above, representing in the natural polypeptide WT1. Compounds enhance or induce the immune response for WT1 and can be used in treatment of leucosis and cancer.

EFFECT: valuable medicinal properties of compositions.

8 cl, 49 tbl, 28 dwg, 6 ex