FIELD: biotechnologies.
SUBSTANCE: proposed peptides represent T-cell epitopes of an endothelial marker of a tumour (TEM8), which are able to induce cytotoxic T-lymphocytes (CTL) in presence of antigen-presenting cells or exosome, which carry or contain HLA-A*0201. A pharmaceutical composition is proposed for elimination of cells expressing TEM8, extracted exosome and antigen-presenting cell, which carry a complex containing a peptide as per invention with HLA-A*0201 molecule. Methods for induction of an antigen-presenting cell, which can induce CTL that destroy the cells expressing TEM8, as well as cytotoxic cells induction methods have been considered.
EFFECT: invention can be further used for cancer therapy.
10 cl, 5 dwg, 1 tbl
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