FLUORINATED DERIVATIVES OF 2-AROYL-3-METHYL-6,7-DIFLUOROBENZ[4,5]-IMIDAZO[1,2-B][1,3]-THIAZOLES AS INHIBITORS OF MEASLES VIRUS REPRODUCTION Russian patent published in 2004 - IPC

Abstract RU 2238093 C1

FIELD: organic chemistry, molecular biology, virology, medicine.

SUBSTANCE: invention relates to the compound 2-aroyl-3-methyl-6,7-difluorobenz[4,5]-imidazo[2,1-b][1,3]-thiazoles of the general formula (1a-o):

wherein R means hydrogen, bromine, chlorine atom, hydroxy-group, group -NHCOCH3, group -OCOCH3, nitro-group, methyl, methoxy-group or phenyl that effective inhibitors of measles virus. Compounds of formulas (1a) and (1b) given in the description elicit ability to inhibit reproduction of measles virus in transplantable cultured cells Vero of green monkey kidney. Antiviral activity of compound (1a) with respect to measles virus exceeds activity of ribavirin significantly.

EFFECT: expanded assortment of agents of indicated designation, valuable antiviral properties of compound.

1 tbl, 2 dwg, 6 ex

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RU 2 238 093 C1

Authors

Pokrovskij A.G.

Il'Icheva T.N.

Kotovskaja S.K.

Chupakhin O.N.

Charushin V.N.

Romanova S.A.

Dates

2004-10-20Published

2003-08-07Filed