FIELD: organic chemistry, molecular biology, virology, medicine.
SUBSTANCE: invention relates to the compound 2-aroyl-3-methyl-6,7-difluorobenz[4,5]-imidazo[2,1-b][1,3]-thiazoles of the general formula (1a-o):
wherein R means hydrogen, bromine, chlorine atom, hydroxy-group, group -NHCOCH3, group -OCOCH3, nitro-group, methyl, methoxy-group or phenyl that effective inhibitors of measles virus. Compounds of formulas (1a) and (1b) given in the description elicit ability to inhibit reproduction of measles virus in transplantable cultured cells Vero of green monkey kidney. Antiviral activity of compound (1a) with respect to measles virus exceeds activity of ribavirin significantly.
EFFECT: expanded assortment of agents of indicated designation, valuable antiviral properties of compound.
1 tbl, 2 dwg, 6 ex
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Authors
Dates
2004-10-20—Published
2003-08-07—Filed