FIELD: organic chemistry of natural compounds.
SUBSTANCE: invention relates to novel compounds, namely, to N'-{N-[3-oxo-lupan-28-oyl]-9-aminononanoyl}-3-amino-3-phenylpropionic acid and its salts of the formula (I) given in the invention description. This compound shows antiviral activity, in particular, anti-HIV activity, and immunostimulating activity. Compounds of the formula (I) are nontoxic and can be obtained from betulin isolated from birch bark as available raw with the high yield.
EFFECT: valuable medicinal properties of compound.
4 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| N'-{N-[3-OXO-20[29]LUPEN-28-OYL]-9-AMINONONANOYL}-3-AMINO-3-PHENYLPROPIONIC ACID ELICITING IMMUNO-STIMULATING AND ANTIVIRAL ACTIVITY | 2002 |
|
RU2211843C1 |
| LUPANE DIPEPTIDE PROCESS | 2007 |
|
RU2357973C1 |
| N-[3-OXO-LUPANO-28-YL]-PIPERIDINE - AGENT HAVING ANTI-TUMOUR, ANTI-METASTATIC, ANTI-INFLAMMATORY AND CYTOPROTECTIVE ACTIVITY | 2011 |
|
RU2466136C1 |
| HYDROGENATED BETULONIC ACID AND AMIDES THEREOF AS TRITERPENE ANTI-TUMOUR AGENTS | 2010 |
|
RU2448115C1 |
| 3-HYDROXIMINO DERIVATIVES OF 2,3-SECOLUPANE TYPE, DEMONSTRATING INHIBITING ACTIVITY WITH RESPECT TO INFLUENZA A AND HIV-1 VIRUS | 2011 |
|
RU2475476C1 |
| LUPANE A-SECO-TRITERPENOIDS EXHIBITING ANTIVIRAL ACTIVITY | 2011 |
|
RU2470003C1 |
| N-[3-OXO-LUPANO-28-YL]-MORPHOLINE - AGENT FOR CORRECTION OF CYTOTOXIC LIVER DAMAGES WITH ANTITUMOUR AND ANTIMETASTATIC ACTIVITY | 2011 |
|
RU2461563C1 |
| PHARMACEUTICAL SALTS OF 3-O-(3',3-DIMETHYLSUCCINYL) BETULINIC ACID | 2005 |
|
RU2387665C2 |
| GLYCYRRHIZIC ACID GLYCOPEPTIDE WITH GLYCYL-L-PHENYLALANINE ELICITING ANTI-HIV-1 ACTIVITY | 2006 |
|
RU2315058C1 |
| AGENT REPRESENTING 3-O-β-D-GLUCOPYRANOSYL-β-D-GLUCOPYRANOSIDE OLEAN-9( 11), 12( 13)-DIENE-30-ACID SHOWING ANTI-HIV-1 ACTIVITY, AND METHOD FOR PREPARING IT | 2011 |
|
RU2475246C2 |
