FIELD: medicine.
SUBSTANCE: the present innovation deals with annexin derivatives with endogenic sites of chelation to be applied in diagnostics of thrombosis. The innovation deals with modified annexins having N-terminal site of chelation containing amino acid-lengthening segment. The latter contains amino acid sequence X1-Gly-X2, where X1 and X2 are chosen out of Gly and Cys and where, at least, one out of X1 or X2 is Cys. Moreover, radionuclides are easily chelated by these modified annexins at obtaining radioactively labeled annexins. The annexins obtained could be applied in diagnostics of thrombosis and apoptosis in vivo.
EFFECT: higher efficiency.
27 cl, 2 dwg, 5 ex, 4 tbl
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