FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to an antibody or its antigen-binding fragment with the specificity of binding to a prostate-specific antigen (PSA). Isolated nucleic acid encoding the specified antibody, an expression vector containing the specified nucleic acid, a host cell containing the specified vector, a pharmaceutical composition, a conjugate, a set containing the specified antibody are also disclosed. The method for producing the specified antibody, the use of the specified antibody for the production of a drug for the treatment or diagnostics of prostate cancer, a method for the treatment or diagnostics using the specified antibody are disclosed.
EFFECT: invention makes it possible to effectively treat disorders associated with the specificity of binding to a prostate-specific antigen (PSA).
80 cl, 5 dwg, 3 tbl, 6 ex
Title | Year | Author | Number |
---|---|---|---|
ANTIBODY AGAINST CLAUDIN 18A2 AND ITS USE | 2020 |
|
RU2811431C2 |
IMPROVED ANTIGEN-BINDING RECEPTORS | 2018 |
|
RU2825816C2 |
ANTIBODIES AGAINST HUMAN VSIG4 AND APPLICATION THEREOF | 2019 |
|
RU2776638C1 |
POLYSPECIFIC BINDING PROTEINS TARGETING NKG2D, CD16 AND TROP2 | 2018 |
|
RU2820629C2 |
POLY-SPECIFIC BINDING PROTEINS TARGETED TO CAIX, ANO1, MESOTHELIN, TROP2, CEA, AND CLAUDINE-18.2 | 2018 |
|
RU2792671C2 |
METHODS FOR DETECTING FOLATE RECEPTOR 1 IN PATIENT SAMPLE | 2018 |
|
RU2759410C2 |
ANTIBODIES B7-H4 AND METHODS FOR THEIR APPLICATION | 2019 |
|
RU2809243C2 |
ANTI-DR5 ANTIBODY AND USE THEREOF | 2018 |
|
RU2735956C1 |
HUMAN NOTCH4 ANTIBODY | 2016 |
|
RU2720280C2 |
BINDING MOLECULES SPECIFIC FOR CD73, AND METHODS OF THEIR APPLICATION | 2015 |
|
RU2730665C2 |
Authors
Dates
2021-08-19—Published
2016-10-04—Filed