FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to polynucleotide encoding induced caspase polypeptide, to polynucleotide containing a nucleotide sequence encoding ligand binding region, a nucleotide sequence encoding a linker, and a nucleotide sequence encoding truncated caspase 9 polypeptide, as well as to a composition, a vector and a cell containing it. Induced caspase polypeptide is also disclosed, as well as a method for modifying cell therapy in a subject who needs it, including introducing the above-mentioned cell to the subject. The invention also relates to a method for the treatment of a disease or disorder in a subject, providing the introduction of the above-mentioned polynucleotide to the subject.
EFFECT: invention allows for selective inducing apoptosis in genetically modified cells.
29 cl, 6 dwg, 2 ex
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