FIELD: organic chemistry.
SUBSTANCE: invention relates to compounds of the formula (1):
wherein R1, R2 and R3 represent independently one or more similar or different substitutes taken among the group consisting of hydrogen, halogen atom, hydroxy-group, mercapto-group, trifluoromethyl, amino-group, (C1-C3)-alkyl, (C2-C3)-olefin group, (C1-C3)-alkoxy-group, (C1-C3)-alkylthio-group, (C1-C6)-alkylamino-group, (C1-C3)-alkoxycarbonyl, cyano-group, carbamoyl or phenyl; R1 and R2 are represented by nitro-group and R3 - by carboxy-group additionally; R4 represents hydrogen atom, (C1-C3)-alkyl or allyl; Q represents a bond or -C(R6)(R7)(-O-C=O)- wherein R6 and R7 mean independently hydrogen atom, trifluoromethyl or (C1-C4)-alkyl; Y represents either (C5-C15)-alkyl, (C2-C15)-olefin group, (C3-C10)-monocyclic hydrocarbon or phenyl being each of that can be substituted optionally with one or more similar or different substituted represented by the formula R5; or Y represents (C5-C6)-alkyl, (C2-C6)-alkenyl, (C3-C6)-cycloalkyl, (C5-C8)-cycloalkene group or phenyl bein each can be substituted optionally with one or more similar or different substituted taken among the group including halogen atom, hydroxy-group, amino-group, (C1-C2)-alkoxy-group, (C1-C4)-alkylamino-group, (C1-C3)-alkoxycarbonyl, cyano-group, azido-group, -COOH, -CONH2, -CONHR' or -CONRR', wherein R and R' mean (C1-C2)-alkyl; or Y represents (C1-C4)-alkyl substituted with at least one or more substituted of the formula R5 or -CONRR' wherein R and R' mean (C1-C2)-alkyl; or Y represents group of the formula -CH2-(Z-O)n-Z wherein Z represents (C1-C3)-alkyl and wherein n represents a whole number > 1 being without continuous linear sequence of atoms in the group Y > 15; R5 represents halogen atom, hydroxy-group, mercapto-group, trifluoromethyl, amino-group, (C1-C3)-alkoxy-group, (C1-C3)-alkylthio-group, (C1-C6)-alkylamino-group, (C1-C3)-alkoxycarbonyl, cyano-group, azido-group, nitro-group, -COOH, -CONH2, -CONHR', -COONR'R' wherein R' means (C1-C3)-alkyl; X means oxygen or sulfur atom; or pharmaceutically acceptable salts of this compound, or hydrates of this compound, or solvates of this compound that can be used for treatment of humans in veterinary science.
EFFECT: valuable medicinal and veterinary properties of compounds.
8 cl, 2 tbl, 31 ex
