FIELD: pharmacognosy, medicine, phytotherapy, pharmacy.
SUBSTANCE: invention relates to a method for preparing Tanacetum parthenium extracts free of α-unsaturated γ-lactones. Method involves carrying out the following stages: a) extraction of plant above ground parts with acetone, alcohols or their mixtures with water; b) extraction of material obtained at stage a) with hydrocarbons; c) extraction of non-hydrocarbon phase with non-polar solvent; d) treatment of extract preliminary evaporated and repeatedly dissolved in an aqueous-alcoholic solution wherein this extract is prepared by using non-polar solvent, strong basic ion-exchange resin; e) eluting resin with alcohols and removing the eluted solution; f) treatment of indicated resin with alcoholic or an aqueous-alcoholic solutions of acids, concentrating solution and extraction of final extract with non-polar solvent; g) evaporating non-polar solution from the stage f) to obtain residue that is added to residue obtained by evaporating hydrocarbon extract from the stage b) and to acetone or alcoholic phase obtained after extraction with non-polar solvent at the stage c); h) evaporation and drying. Pharmaceutical composition eliciting an anti-migraine activity contains indicated extract. Invention provides reducing allerginicity of extract.
EFFECT: improved preparing method, valuable medicinal properties of extract.
5 cl, 1 tbl, 1 dwg, 2 ex
