FIELD: biotechnology, microbiological industry.
SUBSTANCE: strain Streptomyces cinnamomensis AC-1638 that is a producer of veterinary antibiotic cocidiostatic monensin is prepared from the strain S. cinnamomensis S-1009 by treatment with nitrosoguanidine and selection in agarized medium containing antibiotic chloramphenicol followed by isolation of mutants resistant to chloramphenicol in the concentration 50 mcg/ml and selection of variants among them with the maximal production of antibiotic monensin. The strain VKPM AC-1638 shows productivity above 35 g/l at the regulated fermentation process with the content of monensin A 85%, not less, of the monensins complex. This allows using the new strain for profitable industrial manufacturing monensins.
EFFECT: valuable properties of strain, high yield of monensin A.
2 ex
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