FIELD: organic chemistry, medicine.
SUBSTANCE: invention describes 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-[4.3.0]-nonane-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid of the formula (I):
in the crystalline modification B and a medicinal agent based on thereof that elicits effect against pathogenic microorganisms. Indicated modification of compound of the formula (I) shows stability and insignificant absorption of air moisture ant doesn't convert to another crystalline modification or amorphous form being even in the prolonged storage.
EFFECT: valuable properties of agent.
4 cl, 4 dwg, 6 ex
Title |
Year |
Author |
Number |
8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION D AND MEDICINAL AGENT ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
2000 |
- Khimmler Tomas
- Rast Khubert
|
RU2248357C2 |
8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID SEMIHYDROCHLORIDE |
1999 |
- Khimmler Tomas
- Rast Khubert
|
RU2242475C2 |
8-CYANO-1-CYCLOPROPYL-7-(1S,6S)-2,8-DIAZABICYCLO- [4.3.0]-NONANE-8-YL)-6- FL UORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID WITH CRYSTALLINE MODIFICATION A AND DRUG ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
1999 |
- Khimmler Tomas
- Khalenbakh Verner
- Rast Khubert
|
RU2247122C2 |
8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION C AND MEDICINAL AGENT ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
2000 |
- Rast Khubert
- Khimmler Tomas
|
RU2248356C2 |
TRIHYDRATE OF 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYLCO-[4,3,0]NONAN-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID |
2005 |
- Rast Khubert
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- Grunenberg Al'Fons
- Khallenbakh Verner
- Bennet-Bukhkhol'Ts Khordi
|
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FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITION ELICITING ANTI-BACTERIAL ACTIVITY |
1997 |
- Shtefan Bartel'
- Tomas Ech
- Tomas Khimmler
- Khans-Georg Rast
- Verner Khallenbakh
- Ehrnst Khajnen
- Frants Pirro
- Martin Sheer
- Mikhael' Shtegemann
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- Khajnts-Georg Vettsshtajn
|
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1993 |
- Uve Peterzen[De]
- Andreas Krebs[De]
- Tomas Shenke[De]
- Tomas Filipps[De]
- Klaus Groeh[De]
- Klaus-Diter Bremm[De]
- Rajner Ehndermann[De]
- Karl-Georg Mettsger[De]
- Ingo Khaller[De]
|
RU2105770C1 |
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1996 |
- Al'Fons Grunenberg
- Patrik Boshe
|
RU2162468C2 |
DERIVATIVES OF QUINOLINE CARBOXYLIC ACID, MIXTURE OF ISOMERS OR INDIVIDUAL ISOMERS, THEIR PHARMACEUTICALLY ACCEPTABLE HYDRATES AND SALTS, METHOD FOR THEIR PRODUCTION |
1992 |
- Uve Petersen[De]
- Tomas Khimmler[De]
- Tomas Shenke[De]
- Andreas Krebs[De]
- Klaus Grokhe[De]
- Klaus-Diter Bremm[De]
- Karl-Georg Mettsger[De]
- Rajner Ehndermann[De]
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|
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1995 |
- Uve Petersen
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