FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention describes 8-cyclo-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-[4.3.0]-nonane-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid of the formula (I):
in crystalline modification D and a medicinal agent based on thereof eliciting effect against pathogenic microorganisms. The prepared crystalline form of compound of the formula (I) shows low hygroscopicity and can be processed to galenic preparations easily and it has the highest filled density and satisfied fluidity.
EFFECT: valuable properties of agent.
4 cl, 7 dwg, 1 ex
| Title |
Year |
Author |
Number |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION B AND MEDICINAL AGENT BASED ON THEREOF ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
1999 |
- Khimmler Tomas
- Khallenbakh Verner
- Rast Khubert
|
RU2248355C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S)-2,8-DIAZABICYCLO- [4.3.0]-NONANE-8-YL)-6- FL UORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID WITH CRYSTALLINE MODIFICATION A AND DRUG ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
1999 |
- Khimmler Tomas
- Khalenbakh Verner
- Rast Khubert
|
RU2247122C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID SEMIHYDROCHLORIDE |
1999 |
- Khimmler Tomas
- Rast Khubert
|
RU2242475C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION C AND MEDICINAL AGENT ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
2000 |
- Rast Khubert
- Khimmler Tomas
|
RU2248356C2 |
| TRIHYDRATE OF 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYLCO-[4,3,0]NONAN-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID |
2005 |
- Rast Khubert
- Kheep Iris
- Grunenberg Al'Fons
- Khallenbakh Verner
- Bennet-Bukhkhol'Ts Khordi
|
RU2383543C2 |
| FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITION ELICITING ANTI-BACTERIAL ACTIVITY |
1997 |
- Shtefan Bartel'
- Tomas Ech
- Tomas Khimmler
- Khans-Georg Rast
- Verner Khallenbakh
- Ehrnst Khajnen
- Frants Pirro
- Martin Sheer
- Mikhael' Shtegemann
- Khans-Peter Shtupp
- Khajnts-Georg Vettsshtajn
|
RU2173318C2 |
| QUINOLONE-AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES IN ADMIXTURE WITH ISOMERS OR INDIVIDUAL ISOMERS, HYDRATES AND SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION |
1993 |
- Uve Peterzen[De]
- Andreas Krebs[De]
- Tomas Shenke[De]
- Tomas Filipps[De]
- Klaus Groeh[De]
- Klaus-Diter Bremm[De]
- Rajner Ehndermann[De]
- Karl-Georg Mettsger[De]
- Ingo Khaller[De]
|
RU2105770C1 |
| 1-CYCLOPROPYL-7-([S,S]-2,8-DIAZABICYCLO[4,3,0]NONE-8-YL)-6- -FLUORO-1,4-DIHYDRO-8-METHOXY-4-OXO-3-QUINOLINE CARBOXYLIC ACID HYDROCHLORIDE MONOHYDRATE AND PHARMACEUTICAL COMPOSITION WITH ANTIBACTERIAL ACTIVITY |
1996 |
- Al'Fons Grunenberg
- Patrik Boshe
|
RU2162468C2 |
| DERIVATIVES OF QUINOLINE CARBOXYLIC ACID, MIXTURE OF ISOMERS OR INDIVIDUAL ISOMERS, THEIR PHARMACEUTICALLY ACCEPTABLE HYDRATES AND SALTS, METHOD FOR THEIR PRODUCTION |
1992 |
- Uve Petersen[De]
- Tomas Khimmler[De]
- Tomas Shenke[De]
- Andreas Krebs[De]
- Klaus Grokhe[De]
- Klaus-Diter Bremm[De]
- Karl-Georg Mettsger[De]
- Rajner Ehndermann[De]
- Khans-Joakhim Tsejler[De]
|
RU2077533C1 |
| QUINOLONE- AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES, MIXTURE OF THEIR ISOMERS OR INDIVIDUAL ISOMERS IN THE FORM OF HYDRATES AND SALTS SHOWING ANTIBACTERIAL ACTIVITY, ISOINDOLE DERIVATIVES AS INTERMEDIATES FOR PREPARATION OF SAID QUINOLONE- AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES |
1995 |
- Uve Petersen
- Tomas Shenke
- Klaus-Diter Bremm
- Rajner Ehndermann
|
RU2145604C1 |
