FIELD: biotechnology, medicine, infectious diseases, medicinal microbiology.
SUBSTANCE: invention relates to a composition designated for treatment and prophylaxis of infections caused by Neisseria microorganism that comprises the following components: (a) protein with amino acid sequence similar by 65% and above with the natural Neisseria protein of a single species (the first group of amino acid sequences is given in the text) and/or its fragment consisting of 10 and more amino acids and eliciting antigen properties; (b) the second protein with amino acid sequence similar by 65% and above with the natural Neisseria protein of another species (the second group of amino acid sequences with even numbers is given in the text), and/or its fragment consisting of 10 or more amino acids and eliciting antigen properties; in particular, the second protein represents NspA. The composition comprises additionally adjuvant. The composition is used both a medicinal agent and for manufacturing the medicinal agent. Applying the invention provides enhancing the effectiveness of prophylaxis or treatment due to the universal effect of the composition (vaccine). Invention can be used in medicine for treatment of infections.
EFFECT: valuable medicinal properties of composition.
8 cl, 137 dwg, 5 tbl, 12 ex
Title | Year | Author | Number |
---|---|---|---|
NEISSERIA ANTIGENS | 1998 |
|
RU2347813C2 |
PROTEIN NMB0928 AND ITS APPLICATION IN PHARMACEUTICAL COMPOSITIONS | 2004 |
|
RU2335505C2 |
HETEROLOGOUS EXPRESSION OF NEISSERIA PROTEINS | 2001 |
|
RU2299906C2 |
HYBRID EXPRESSION OF NEISSERIA PROTEINS | 2001 |
|
RU2304617C2 |
VERSIONS OF FACTOR N-BINDING PROTEIN AND METHODS OF USE THEREOF | 2015 |
|
RU2714248C2 |
COMPOSITIONS INCLUDING NEISSERIA MENINGITIDIS ANTIGENS FROM B AND C SEROGROUPS, AND ADDITIONAL ANTIGEN | 2000 |
|
RU2361609C2 |
COMPOSITIONS CONTAINING NEISSERIA Meningitidis serogroup B AND C ANTIGENS, AND ADDITIONAL ANTIGEN | 2000 |
|
RU2508122C2 |
MOLECULAR MIMETICS OF MENINGOCOCCUS B EPITOPE THAT INDUCE PRODUCTION OF FUNCTIONALLY ACTIVE ANTIBODY | 2002 |
|
RU2322451C2 |
OUTER MEMBRANE VESICLE VACCINE (OMV) CONTAINING PROTEINS OF SEROGROUP B N.Meningitis OUTER MEMBRANE | 2001 |
|
RU2279889C2 |
KIT FOR PREPARING IMMUNOGENIC COMPOSITION FOR SEROGROUP B Neisseria meningitidis | 2008 |
|
RU2498815C2 |
Authors
Dates
2005-01-20—Published
2000-05-19—Filed