FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to versions of the factor H-binding proteins, and can be used in medicine for inducing an anti-N. meningitides antibody response in mammals. Produced protein is version of group of versions 1 (v. 1) factor H-binding protein (fHbp) with leucine (L) in amino acid position 248 and optionally serine (S) at position 41 according to number sequence of amino acid sequence fHbp ID1.
EFFECT: invention provides a version of fHbp, which binds human factor H (fH) with affinity of 50 % or less from affinity fHbp ID 55 for human fH and causes a bactericidal humoral response to at least one Neisseria meningitidis strain in mammalian body.
22 cl, 40 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| OPTIONS FOR H-BINDING PROTEIN FACTOR AND METHODS OF THEIR USE | 2015 |
|
RU2811942C2 |
| MODIFIED PROTEIN BINDING FACTOR H | 2017 |
|
RU2773464C1 |
| NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS FOR USING THEM | 2017 |
|
RU2739504C2 |
| COMPOSITION FOR CULTURING NATURAL KILLER CELLS AND METHOD OF PRODUCING NATURAL KILLER CELLS USING SAME | 2020 |
|
RU2824216C1 |
| METHODS FOR DETECTING FOLATE RECEPTOR 1 IN PATIENT SAMPLE | 2018 |
|
RU2759410C2 |
| ANTIBODY AGAINST SIRPα | 2019 |
|
RU2791002C2 |
| ANTIBODIES TO MYOSTATIN, POLYPEPTIDES CONTAINING FC-REGION VARIANTS, AND THEIR APPLICATION METHODS | 2016 |
|
RU2789884C2 |
| COMPOSITION FOR PREVENTION OR TREATMENT OF IL-8-RELATED DISEASES | 2017 |
|
RU2766112C2 |
| FUSED PROTEIN CONSTRUCTS FOR COMPLEMENT-RELATED DISEASE | 2019 |
|
RU2824402C2 |
| BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO PD1 AND LAG3 | 2018 |
|
RU2778805C2 |
