ACYLBENZOXAZINES FOR ENHANCING SYNAPTIC RESPONSE(S) Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates in particular to derivatives of acylbenzoxazine of the formula: wherein radicals X¹ and X² are taken independently among hydrogen atom, -OR³, -CH₂OR³, or taken in common they represent -OCR42

O-, -OC₂R44O-, -OC₂R42O- wherein in each case R in residue (CR₂) represents hydrogen atom, oxy-group, (C₁-C₆)-alkoxy; R³ represents hydrogen atom, (C₁-C₆)-alkyl; in each case radical R¹ represents hydrogen atom or (C₁-C₆)-alkyl; in each case radical R⁴ represents hydrogen atom or (C₁-C₆)-alkyl; n = 1, 2, 3 or 4. Compounds elicit the higher effect as compared with corresponding benzoylpiperidines for enhancing the synaptic responses mediated by AMPA-receptors. Also, invention relates to methods for their using for treatment of patients suffering with disorders in nervous and intellectual activity as result of insufficiency in function of some excitement synapses or in some AMPA-receptors. Compounds of the present invention can be used for treatment of patients without indicated disorders for enhancing activity associated with sensomotor and cognitive tasks that depend on the brain reticular structure using AMPA-receptors and for improving the memory encoding.

EFFECT: valuable biological and medicinal properties of compounds.

13 cl, 1 tbl, 5 ex