GLYCEROL DERIVATIVES AND A METHOD OF THEIR SYNTHESIS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: derivatives of glycerol of the general formula (I) where A is taken from the group of the formula: (1) where R₂, R₃ and R₄ lower alkoxy-group; (2) where R₅ hydrogen, alkyl or , p=1 or 2; (3) where X a group -CH- or nitrogen atom; R₆ a group -COR₇ where R₇ alkyl or alkoxy, or a group -O-CO-NH-R₈ where R₈ alkyl; (4) ; (5) -NH-(CH₂)₃-OR₁₀ where R₁₀ alkyl; (6) -NH-(CH₂)₁₀-NH-CO-NR₁₁R₁₂ where R₁₁ and R₁₂ lower alkyl; (7) where R₁₃ lower alkoxycarbonyl; (8) ; (9) -NH-(CH₂)₅-O-(CH₂)₅-O-(CH₂)₅-H; (10) -NH-(CH₂)₃-O-CO-NH-R₁₄ where R₁₄ alkyl; (11) ; (12) where m=0 or from 1 to 6; R₉, R₁₅ and R₁₆ are similar or different and mean hydrogen or alkoxy-group; B lower alkyl or arylalkyl; R₁ - acetyl, 2-alkoxybenzoyl or aryl; k=1 or 0; n= 0 or the whole number from 1 to 3; Y a group of the formula or at condition that when k=0 then the group A is obligatory formula (12), B alkyl and R₁ aryl, and a method of their synthesis by acylation of compound of the general formula (II) where A, B and n as indicated above with reactive derivative of carboxylic acid of the formula R₁OH where R₁ as indicated above. EFFECT: improved method of synthesis. 3 cl, 5 tbl