METHOD FOR PREDICTING PRE-CLINICAL STAGE OF EPILEPSY Russian patent published in 2005 - IPC

FIELD: medicine, psychiatry, neurology.

SUBSTANCE: the present innovation deals with the ways to detect latent epileptogenesis that provides the chance to evaluate the degree of its compensation or mobility and enables to improve diagnostics of epilepsy at its pre-clinical stage. One should carry out electroencephalographic monitoring by calculating fractal dimensionality of spectral power fluctuation α and biochemical testing paroxysmal cerebral activity due to a test system that enables to detect blood level of autoantibodies to glutamate-binding membranous cerebral protein, moreover, additionally, one should evaluate immune homeostasis, detect the level of total thiolic groups of proteins (SH-groups) in blood serum due to calorimetric technique based upon interaction of molecular iodine with free sulfhydrylic groups of proteins, and spectrophotometrically evaluate the content of average-molecular oligopeptides (AMP), moreover, the values of SH-groups being equal to 2.87-3.42 mM/l and AMP values being equal to 2.89-3.38 g/l in combination with other values prove the availability of pre-clinical stage of epilepsy in patients.

EFFECT: higher accuracy of diagnostics.

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