ENHANCEMENT OF IMMUNE RESPONSES MEDIATED BY PROTEINS FUSED FROM ANTIBODY AND CYTOKINE BY METHOD OF COMBINED ADMINISTRATION OF ANGIOGENESIS INHIBITOR Russian patent published in 2004 - IPC

FIELD: medicine, immunology. SUBSTANCE: invention reports about compositions and methods for enhancement of cytocide immune responses directed against preliminary taken cells type in mammals. Methods and compositions are based on the combination of immunoconjugate of type antibody-cytokine and angiogenesis inhibitor. In administration to mammal the immunoconjugate induces the response against preliminary taken cells type, for example, cancer cells that as result of synergetic effect with angiogenesis inhibitor exceeds the immune response induced by a single immunoconjugate. Methods and compositions are useful especially for eradication solid tumors or virus-infected mammalian cells. EFFECT: expanded assortment of immunomodulating agents. 27 cl, 5 dwg