IMIDAZOQUINOLINES, PHARMACEUTICAL PREPARATION AND METHOD FOR INDUCTION OF CYTOKINE BIOSYNTHESIS BASED ON THEREOF Russian patent published in 2005 - IPC

Abstract RU 2248975 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new imidazoquinolines of the formula (1): wherein R, R₁, R₂ and n have values given in the description. Compounds elicit effect of immunomodulating agents inducing biosynthesis of cytokines in animals in treatment of different pathologies, among them viral and neoplastic diseases. Also, invention relates to a pharmaceutical preparation used for inducing interferon-α or tumor necrosis α-factor, to a method for inducing biosynthesis of cytokines in animals and to methods for treatment of viral diseases and neoplasm pathologies in animals. Invention provides preparing new biologically active compounds.

EFFECT: improved inducing method, valuable properties of compounds and pharmaceutical preparation.

23 cl, 10 tbl, 231 ex

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RU 2 248 975 C2

Authors

Kruks Stefen L.

Lindstrom Kajl Dzh.

Merrill Brajon A.

Rajs Majkl Dzh.

Dates

2005-03-27—Published

2000-06-08—Filed