THIOESTER-SUBSTITUTED IMIDAZOQUINOLINES Russian patent published in 2008 - IPC C07D471/04 A61K31/37 A61P35/00 A61P31/00

Abstract RU 2315049 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes imidazoquinoline derivatives of the formula (I): wherein X represents alkyl, -CHR₃-; Z represents groups -S-. -SO-, or -SO₂-; R₁ is chosen from group comprising alkyl and unsubstituted phenyl; R₂ is chosen from group comprising hydrogen atom, alkyl, alkyl-Y-alkyl; each R₃ represents hydrogen atom; Y represents -O-; n = 0. Also, invention describes a tetraimidazoquinoline derivative, pharmaceutical compositions based on thereof and a method for stimulating biosynthesis of cytokine in animal body. Proposed compounds and compositions can induce biosynthesis of different cytokines and therefore they can be used in treatment of different diseases being among them viral and tumor diseases.

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

20 cl, 1 tbl, 20 ex

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RU 2 315 049 C2

Authors

Dellaria Dzhozef F.

Merrill Brajon A.

Radmer Mehtt'Ju R.

Dates

2008-01-20—Published

2001-12-06—Filed