FIELD: organic chemistry, pharmaceuticals.
SUBSTANCE: invention relates to arylether-substituted imidazoquinolines and tetrahydroimidazoquinolines useful in inducing of cytokines biosynthesis. In particular described are imidazoquinolines of formula I
wherein X represents -CHR3; R1 represents aryl, R4-aryl; R2 represents hydrogen atom, alkyl, aryl, tetrahydrofuran; alkyl-Y-alkyl; alkyl-Y-aryl, and alkyl substituted with one or more substituents; R are independently C1-C10-alkyl, C1-C10- alkoxy, hydroxyl group; halogen atom, and trifluoromethyl or pharmaceutically acceptable salts thereof; meanings of the rest substituents are as defined in description. Also disclosed are pharmaceutical compositions for inducing of cytokines biosynthesis, methods for treatment of viral and tumor diseases.
EFFECT: new compounds with value biological properties.
39 cl, 8 tbl, 146 ex
Title |
Year |
Author |
Number |
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2001 |
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|
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|
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|
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