SERINE PROTEASE INHIBITORS, PHARMACEUTICAL COMPOSITION AND THERAPEUTICAL METHODS BASED ON THE SAME Russian patent published in 2005 - IPC

FIELD: pharmaceutical industry, medicine.

SUBSTANCE: invention relates to new compounds of formula

,

wherein A and B are independently CH or CR₃; X is C=O or (CR_4aR_4b)_m, (m = 1 or 2); Y is S(O)_n-R₂ (n = 1 or 2), S(O)_n-NR₂R₂, or S(O)_n-OR₂; N₁ and N₂ are nitrogen atoms; Q and R₁ are independently 1) optionally substituted C₁-C₁₀-alkyl; 2) optionally substituted aralkyl containing C₆-C₁₀-aryl, attached to C₁-C₁₀-alkyl; 3) optionally substituted aralkenyl containing C₅-C₁₀-aryl, attached to C₁-C₁₀-alkenyl; 4) optionally substituted C₆-C₁₀-aryl; 5) optionally substituted aryl, containing 5-10 ring atoms, selected from carbon and sulfur; each R₂ and R₃ are hydrogen; R_4a, R_4b, R₅, and R₆, are independently hydrogen; R₂ and R₃ are independently hydrogen or C₁-C₆-alkyl; as well as acid and base additive salts thereof. Also disclosed are method for production of claimed compounds, pharmaceutical composition inhibiting serine protease enzymes and therapeutic method based thereon.

EFFECT: new compounds and pharmaceutical composition for thrombosis preventing or abnormal thrombosis treatment.

11 cl, 7 tbl, 15 ex