DERIVATIVES OF 3-SUBSTITUTED 1,5-DIPHENYLPYRAZOLE EFFECTIVE AS CB1 MODULATORS Russian patent published in 2009 - IPC C07D231/14 C07D401/12 C07D405/12 C07D409/12 A61K31/415 A61K31/4439 A61K31/454 A61K31/5377 A61P25/00 A61P3/04 

FIELD: medicine.

SUBSTANCE: invention covers compound of formula (IA) or to its pharmaceutically acceptable salts wherein R¹ represents group R⁵S(O)₂O where R⁵ represents C_1-6alkyl group optionally substituted with one or more fluoro; R^a represents halogeno, and m is equal to 0, 1 or 2; R^2a represents chloro; R^2b represents chloro; R^2c represents H or halogeno; R³ represents group CONHNR⁷R⁸ wherein NR⁷R⁸ represents piperidino or morpholino, or R³ represents group CONHR⁸ wherein R⁸ represents C_5-7cycloalkyl group optionally substituted with C_1-6alkoxycarbonyl group, or R⁸ represents pyridyl optionally substituted with one C_1-5alkyl group where said alkyl is optionally substituted with one or more fluoro; and R⁴ represents H, C_1-3alkyl group or halogeno. The compounds of formula (IA) are modulators of CB1 receptors and can find application in manufacturing of a medicinal agent with modulating activity in relation to CB1-receptor which can be used in treatment of obesity, psychiatric and neurologic disturbances.

EFFECT: higher clinical effectiveness.

5 cl, 21 ex