2,5-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES Russian patent published in 2015 - IPC C07D498/04 A61K31/519 A61P17/02 A61P43/00 

Abstract RU 2554874 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to oxazolopyramidine compounds of formula I, where A represents O; R1 is selected from phenyl or pyrimidine, which are optionally substituted with R11; R2 represents phenyl, which is optionally substituted wby 1-3 ring carbon atoms with similar or different substituents R22, R11 represents halogen; R22 is selected from hydroxy group, (C1-C4)-alkyl, which is optionallysubstituted with 1-3 atoms of fluorine, (C1-C4)-alkyloxy, (C1-C4)-alkyl-S(O)m-; m equals 2. Invention also relates to pharmaceutical composition, which contains formula I compounds, and to method of obtaining formula I compounds.

EFFECT: formula I compounds, intended for activation of EDG-1 receptor and applied for wound healing.

15 cl, 2 tbl, 2 ex

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RU 2 554 874 C2

Authors

Kaderajt Diter

Shefer Mattias

Khakhtel' Shtefani

Ditrikh Aksel'

Khjubshle Tomas

Khiss Katrin

Dates

2015-06-27Published

2011-01-12Filed