CARBOXYLIC ACID DERIVATIVES CONTAINING 2,5,7-SUBSTITUTED OXAZOLE PYRIMIDINE RING Russian patent published in 2015 - IPC C07D498/04 A61K31/519 A61P17/02 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to oxazole pyrimidine compounds of formula in any of stereomeric forms thereof or a physiologically acceptable salt thereof, where A is O; X is (C₁-C₆)alkanediiyl oxy; R¹ is (C₁-C₆)alkyl; R² is phenylene, optionally substituted at one or two ring carbon atoms with identical or different R²²; R³ is (C₁-C₆)alkyl, optionally substituted with 1-3 fluorine atoms, or (C₃-C₇) cycloalkyl-C_uH_2u- (u is selected from 1 and 2), or R³ is a residue of a saturated or unsaturated 4-10-member monocyclic or bicyclic ring containing 0, 1, 2 or 3 identical or different heteroatoms in the ring, selected from N, O and S, and is (C₄-C₆)cycloalkyl, indanyl, phenylene, naphthyl, isothiazolyl, thiadiazolyl, pyridyl, benzothiazolyl, quinolinyl, tetrahydrofuranyl, where the ring residue is optionally substituted at one or more ring carbon atoms with R³¹ substitutes; R⁴ is hydrogen; R²² is (C₁-C₄)alkyl; R³¹ is selected from a group consisting of a halogen and (C₁-C₄) alkyl, which is optionally substituted with 1-3 fluorine atoms, (C₁-C₄)alkyloxy, which is optionally substituted with 1-3 fluorine atoms, and (C₁-C₄)alkyl-S(O)_m-, wherein (C₁-C₄)alkyl is optionally substituted with 1-3 fluorine atoms; m equals 0. The invention also relates to a pharmaceutical composition containing a compound of formula I, and to a method of producing compounds of formula I.

EFFECT: invention provides compounds of formula I, which are intended for EDG-1 receptor activation and wound healing.

17 cl, 2 tbl, 2 ex