CARBOXYLIC ACID DERIVATIVES, HAVING OXAZOLE[4,5-D]PYRIMIDINE RING Russian patent published in 2017 - IPC C07D498/04 A61K31/519 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula I or a physiologically acceptable salt thereof, where A denotes an O atom; X denotes (C₃-C₇)-cycloalkanediiyl; R¹ denotes a hydrogen atom; R^2a, R^2b and R^2c denote hydrogen atoms or (C₁-C₄)-alkyls; R³ is a radical of unsaturated 6-membered monocycle, wherein one or more carbon atoms contained in cycle optionally have identical or different substitutes R³¹ or R³ represents a (C₃-C₇)-cycloalkyl-C_uH_2u, where u is selected from 1 and 2; R³¹ denotes a halogen atom or (C₁-C₄)-alkyl; wherein all alkyls, independently from each other and from other substitutes, can optionally have one or more substitutes in form of fluorine atoms. Invention also relates to a pharmaceutical composition for activation of EDG-1 receptors, containing at least one compound of formula I or its physiologically acceptable salt and pharmaceutically acceptable carrier.

EFFECT: technical result is derivatives of carboxylic acids having[4,5-D]pyrimidine ring for use as a medicinal agent for EDG-1 receptor activation.

5 cl, 2 tbl, 2 ex