FIELD: biotechnology, medicine, in particular treatment, prevention and diagnosis of diseases, associated with Neisseria meningitides.
SUBSTANCE: Claimed protein includes one or more N. meningitides protein fragments with known amino acid sequences, wherein said fragment contains one or more antigen determinants and has not more than 1977 amino acid from SEQ ID NO:1 and/or not more than 1531 amino acid from SEQ ID NO:2 which are described in specification with the proviso, that general protein sequence is not characterized by amino acid sequences represented in NO:1 and NO:2. Each claimed protein is encoded by nuclear acid (NA) with nucleotide sequence that defines protein amino acid sequence according to gene code. Peptides and nuclear acid of present invention are useful in drug production for treatment and prophylaxis of infections induced neisseria, as well as in production of diagnostic reagent for detection of neisseria or specific antibodies. Aldo disclosed is peptide- or NA-based pharmaceutical composition in effective amount with acceptable carrier. Said composition is useful for treatment of N. meningitides mediated infection. For prophylaxis composition is applied in vaccine form. Invention makes it possible to overcome diversity of neisseria antigen properties.
EFFECT: improved method for neisseria infection prophylaxis and treatment.
24 cl, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| NEISSERIA ANTIGENIC PEPTIDES | 2000 |
|
RU2284332C2 |
| NEISSERIA ANTIGENE PEPTIDES | 2000 |
|
RU2281956C2 |
| NEISSERIA ANTIGEN, NUCLEIC ACID ENCODING ITS, THEIR APPLYING | 2000 |
|
RU2245366C2 |
| OUTER MEMBRANE VESICLE VACCINE (OMV) CONTAINING PROTEINS OF SEROGROUP B N.Meningitis OUTER MEMBRANE | 2001 |
|
RU2279889C2 |
| PROTEIN OBTAINED FROM NEISSERIA MENINGITIDIS SHOWING ANTIGEN PROPERTY, ANTIBODY, NUCLEIC ACID FRAGMENT (VARIANTS) AND COMPOSITION CONTAINING THEREOF | 1999 |
|
RU2233331C2 |
| PROTEIN CORRESPONDING TO NEISSERIA MENINGITIDIS ANTIGEN PROTEIN AND ELICITING IMMUNOGENIC PROPERTIES (VARIANTS), ANTIBODY BINDING WITH IT, NUCLEOTIDE SEQUENCE (VARIANTS) AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF | 1998 |
|
RU2232191C2 |
| ANTIGENES NEISSERIA MENINGITIDIS | 1999 |
|
RU2343159C2 |
| IMMUNISATION AGAINST CHLAMYDIA TRACHOMATIS | 2002 |
|
RU2331435C2 |
| PROTEIN OBTAINED FROM NEISSERIA MENINGITIDIS ELICITING PROPERTIES OF ANTIGEN, ANTIBODY, NUCLEIC ACID (VARIANTS) AND COMPOSITION CONTAINING THEREOF | 2000 |
|
RU2233328C2 |
| NEISSERIA ANTIGENS | 1998 |
|
RU2347813C2 |
