FIELD: biotechnology, microbiology.
SUBSTANCE: invention relates, in particular, to antigene peptide sequences from microorganism Neisseria meningitides and N. gonorrhoeae. Described proteins comprise fragment of one or more Neisseria proteins with the definite amino acid sequence and the definite amount of amino acid residues (amino acid sequences are given in the invention description). Also, invention describes nucleic acids encoding indicated proteins and their using in preparing a medicinal agent used in treatment and prophylaxis of infection caused by neisseria. Use of protein and nucleic acids as components of the diagnostic reagent for detection of neisseria or antibodies raised to neisseria is proposed. Invention describes the immunogenic composition based on protein or nucleic acids for preparing specific antibodies and its using in treatment of the corresponding infection. Using the invention provides preparing protein vaccines showing effectiveness with respect to N. meningitidis B.
EFFECT: improved preparing method, valuable medicinal properties of peptides.
19 cl, 1 tbl, 1 ex
Title | Year | Author | Number |
---|---|---|---|
NEISSERIA ANTIGEN, NUCLEIC ACID ENCODING ITS, THEIR APPLYING | 2000 |
|
RU2245366C2 |
NEISSERIA ANTIGENIC PEPTIDES | 2000 |
|
RU2284332C2 |
OUTER MEMBRANE VESICLE VACCINE (OMV) CONTAINING PROTEINS OF SEROGROUP B N.Meningitis OUTER MEMBRANE | 2001 |
|
RU2279889C2 |
IMMUNISATION AGAINST CHLAMYDIA TRACHOMATIS | 2002 |
|
RU2331435C2 |
PROTEIN OBTAINED FROM NEISSERIA MENINGITIDIS SHOWING ANTIGEN PROPERTY, ANTIBODY, NUCLEIC ACID FRAGMENT (VARIANTS) AND COMPOSITION CONTAINING THEREOF | 1999 |
|
RU2233331C2 |
PROTEIN CORRESPONDING TO NEISSERIA MENINGITIDIS ANTIGEN PROTEIN AND ELICITING IMMUNOGENIC PROPERTIES (VARIANTS), ANTIBODY BINDING WITH IT, NUCLEOTIDE SEQUENCE (VARIANTS) AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF | 1998 |
|
RU2232191C2 |
ANTIGENES NEISSERIA MENINGITIDIS | 1999 |
|
RU2343159C2 |
PROTEIN OBTAINED FROM NEISSERIA MENINGITIDIS ELICITING PROPERTIES OF ANTIGEN, ANTIBODY, NUCLEIC ACID (VARIANTS) AND COMPOSITION CONTAINING THEREOF | 2000 |
|
RU2233328C2 |
ANTIGEN MENINGOCOCCUS PEPTIDES (VARIANTS) | 2000 |
|
RU2253678C2 |
NEISSERIA ANTIGENS | 1998 |
|
RU2347813C2 |
Authors
Dates
2006-08-20—Published
2000-10-30—Filed