FIELD: medicine; biotechnologies.
SUBSTANCE: amino-acid sequences are presented in the list of the sequences obtained from a bacterium, mainly strains A and B which show properties of an antigene. The invention includes corresponding nucleotide sequences of fragments of the nucleinic acid, coding amino-acid sequences of the specified proteins. The proteins under the invention can be used as antigenes for obtaining of specific antibodies and manufacturing of compositions for treatment, preventive maintenance or diagnostics of the infection caused Neisseria meningitidis. The compositions are prepared on the basis of a protein, a fragment of nucleinic acid or an antibody with addition of the pharmaceutically comprehensible carrier and represent vaccinal, diagnostic or pharmaceutical compositions. Sequences of the obtained proteins have no any considerable homology with sequences Neisseria gonorrhoeae, that allows to receive treatment-and-prophylactic and diagnostic compositions with high specificity in relation to N. meningitidis and also to receive Diagnostic reagents for differentiation N. meningitidis from N. gonorrhoeae.
EFFECT: efficiency of application.
12 cl, 2 tbl, 17 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROTEIN OBTAINED FROM NEISSERIA MENINGITIDIS SHOWING ANTIGEN PROPERTY, ANTIBODY, NUCLEIC ACID FRAGMENT (VARIANTS) AND COMPOSITION CONTAINING THEREOF | 1999 |
|
RU2233331C2 |
| NEISSERIA ANTIGENE PEPTIDES | 2000 |
|
RU2281956C2 |
| OUTER MEMBRANE VESICLE VACCINE (OMV) CONTAINING PROTEINS OF SEROGROUP B N.Meningitis OUTER MEMBRANE | 2001 |
|
RU2279889C2 |
| NEISSERIA ANTIGEN, NUCLEIC ACID ENCODING ITS, THEIR APPLYING | 2000 |
|
RU2245366C2 |
| PROTEIN CORRESPONDING TO NEISSERIA MENINGITIDIS ANTIGEN PROTEIN AND ELICITING IMMUNOGENIC PROPERTIES (VARIANTS), ANTIBODY BINDING WITH IT, NUCLEOTIDE SEQUENCE (VARIANTS) AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF | 1998 |
|
RU2232191C2 |
| NEISSERIA ANTIGENIC PEPTIDES | 2000 |
|
RU2284332C2 |
| ANTIGEN MENINGOCOCCUS PEPTIDES (VARIANTS) | 2000 |
|
RU2253678C2 |
| IMMUNISATION AGAINST CHLAMYDIA TRACHOMATIS | 2002 |
|
RU2331435C2 |
| PROTEIN OBTAINED FROM NEISSERIA MENINGITIDIS ELICITING PROPERTIES OF ANTIGEN, ANTIBODY, NUCLEIC ACID (VARIANTS) AND COMPOSITION CONTAINING THEREOF | 2000 |
|
RU2233328C2 |
| NEISSERIA ANTIGENS | 1998 |
|
RU2347813C2 |
