SILICON GLYCERATES ELICITING TRANSCUTANEOUS CONDUCTIVITY OF MEDICINAL AGENTS AND GLYCEROHYDROGELS BASED ON THEREOF Russian patent published in 2005 - IPC

FIELD: silicon-containing substances, medicine, pharmacy.

SUBSTANCE: invention describes silicon glycerates eliciting transcutaneous conductivity of medicinal agents with the composition of the formula: Si(C₃H₇O₃)₄ x xC₃H₈O₃ wherein 3 ≤ x ≤ 10 with dynamic viscosity 4.6-28.5 Pa x s (20 ± 0.5°C). Compounds are prepared by interaction of tetraethoxysilane with glycerol in the mole ratio = 1:(7-14) in the presence of tetrabutoxy-titanium (0.06 mole/mole of tetraethoxysilane) and removal of formed ethyl alcohol in heating of reaction mass to 120-130°C and keeping at this temperature for 3 h, not less. Also, invention describes glycerohydrogels based on element-organic glycerates containing water and gel-forming additive that contain as element-organic glycerates silicon glycerates with the composition of the formula Si(C₃H₇O₃)₄ x xC₃H₈O₃ wherein 3 ≤ x ≤ 10 as they contain electrolyte as a gel-forming additive in the following ratio of components, wt.-%: silicon glycerates, 8.2-65.1; electrolyte, 0.1-0.6, and water, the balance. Proposed compounds - silicon glycerates and glycerohydrogels based on thereof are physiologically active substances eliciting transcutaneous conductivity of medicinal agents with possible broad spectrum of their applying in medicine.

EFFECT: valuable medicinal properties of compounds.

2 cl, 2 tbl, 2 dwg, 7 ex