WATER-SOLUBLE ORGANOSILICON DERIVATIVES OF POLYOLS AND HYDROGELS BASED ON SAID DERIVATIVES Russian patent published in 2010 - IPC C07F7/18 A61K31/695 

FIELD: chemistry.

SUBSTANCE: water-soluble organosilicon derivatives of polyols are proposed, composition of which has formula (CH₃)_4-nSi(O-R-OH)_n·x HO-R-OH in excess polyol, where R=-CH₂-CH(OH)-CH₂-, -CH₂CH(CH₃)-, (-CH₂-CH₂-O-)_mCH₂-CH₂-, 0.5≤x≤2.9, n=2-4, m=7.7 or 12.0, with dynamic viscosity of 0.8-29.0 Pa·s (20±0.5°C), obtained by reacting (methyl)ethoxysilanes with polyols in molar ratio 1:(2.2-6.9) while heating the reaction mass to 120-130°C, maintaining this temperature for not less than 4 hours while stirring intensely with subsequent removal of the formed alcohol. Synthesis can take place in the presence of a catalyst, for example tetrabutoxy titanium - in amount of 0.04-0.06 mol per mole of (methyl)ethoxysilane. Also proposed a hydrogels based on said organosilicon derivatives of polyols, containing water and a gel-forming additive, with the following ratio of components in wt %: organosilicon derivatives of polyols in excess polyol 44.95 - 98.01; gel-forming additive 0.01-0.50; water - the rest. Proposed water-soluble organosilicon derivatives of polyols and hydrogels based on the said derivatives are physiologically active compounds, exhibit transcutaneous and vulnerary activity, have considerable effect on morphofunctional state of the skin and can be recommended as independent agents and as ointment bases of various pharmaceutical compositions with vulnerary activity.

EFFECT: obtaining novel water-soluble biologically active organosilicon derivatives of polyols which can be used as independent agents with transcutaneous and vulnerary activity and as bases of pharmaceutical compositions for local application.

3 cl, 2 dwg, 2 tbl, 16 ex