SILICON-TITANIUM-CONTAINING POLYOL DERIVATIVES AND HYDROGELS BASED THEREON Russian patent published in 2012 - IPC C07F7/18 C07F7/28 A61K31/695 

FIELD: chemistry.

SUBSTANCE: invention relates to novel biologically active chemical compounds - silicon-titanium-containing polyol derivatives (glycerine, polyethylene glycol), as well as hydrogels based thereon. Disclosed are silicon-titanium-containing polyol derivatives, having transcutaneous, wound healing and regenerating activity, the composition of which in excess of polyol has the formula k(CH₃)_4-nSi(O-R-OH)_n·Ti(O-R-OH)₄·xHO-R-OH, where R=R₁=CH₂-CH(OH)-CH₂: k=1 or 2, n=2 or 3, x=11 or 12; or R=R₂=(CH₂-CH₂-O-)₇,₇CH₂-CH₂: k=1 or 2, n=2-4, x=2 or 3, with dynamic viscosity 1.5-90.0 Pa·s (25±0.5°C), obtained by reacting (methyl)ethoxysilane and tetrabutoxytitanium with polyol in molar ratio (1-2):1:(18-22) for R₁ or (1-2):1:(8-15) for R₂, respectively, while heating the reaction mass to temperature 90-140°C and holding at that temperature for not less than 6 hours with intense stirring, followed by removal of the formed alcohols. The invention also discloses hydrogels based on said polyol derivatives, containing water and a gelling additive, with the following ratio of components (wt %): silicon-titanium-containing polyol derivatives in excess of polyol - 70.730-94.970; gelling additive 0.002-0.060; water - the balance.

EFFECT: silicon-titanium-containing polyol derivatives and hydrogels based thereon are physiologically active compounds, exhibit transcutaneous and wound healing action, have significant effect on the morphofunctional condition of the skin and can be recommended for use as independent agents, as well as ointment bases of different pharmaceutical compositions with transcutaneous, wound healing and regenerating action.

2 cl, 2 dwg, 8 tbl, 6 ex