FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for preparing 5-arylnicotine aldehydes, in particular, 5-(4-fluorophenyl)nicotine aldehyde by reduction of corresponding 5-arylnicotinic acids. Method involves catalytic hydrogenation in the presence of carboxylic acid anhydrides, in particular, trimethylacetic or isobutyric anhydride when palladium-ligand complex is used. The molar ratio of palladium to ligand is from 1:5 to 1:15 in case of monodental ligands and from 1:2.5 to 1:7.5 in case of bidental ligands. Method provides preparing substituted nicotine aldehydes with high yield.
EFFECT: improved method for preparing.
4 cl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING NICOTINALDEHYDES | 2004 |
|
RU2339619C2 |
| METHOD OF PRODUCTION OF COMPOUNDS CONTAINING PALLADIUM (0) | 2003 |
|
RU2334754C2 |
| CHROMANONE DERIVATIVES | 2001 |
|
RU2273638C2 |
| PROCESS FOR PREPARING 2-( 4′-ISOBUTYLPHENYL) PROPIONIC ACID (IBUPROPHENE) OR ITS VERSIONS | 1988 |
|
RU2005715C1 |
| PRODUCING 3-[(1R,2R)-3-(DIMETHYLAMINO)-1-ETHYL-2-METHYLPROPYL]-PHENOL | 2007 |
|
RU2463290C2 |
| DERIVATIVES OF CHROMAN AND METHODS FOR THEIR PREPARING | 1999 |
|
RU2233277C2 |
| SYNTHESIS OF 3-METHYL-1,2,4-THIADIAZOLE-5-CARBOHYDRAZIDE OR ITS METHYL-d DUTERATED FORM | 2019 |
|
RU2804686C2 |
| METHOD OF ADDITIVE POLYMERIZATION OF NORBORNEN AND ITS DERIVATIVES | 2015 |
|
RU2626745C2 |
| METHOD OF PRODUCING NITROGEN MUSTARD DERIVATIVES | 2016 |
|
RU2715233C2 |
| METHOD OF PRODUCING 1-[2-(2,4-DIMETHYL-PHENYLSULPHANYL)PHENYL]PIPERAZINE | 2012 |
|
RU2608307C2 |
