FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to derivatives of chroman of the formula (I):
wherein R1 means acyl with 1-6 carbon atoms; R2, R3, R4 represent hydrogen atom; X means hydrogen or oxygen atom, and to their enantiomers and their salts, and to methods for their preparing also. Invention provides preparing new compounds that can be used as intermediate substances in synthesis of medicinal agents, namely (R)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman eliciting effect on the central nervous system.
EFFECT: improved preparing methods, valuable medicinal properties of compounds.
6 cl, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CHROMANONE DERIVATIVES | 2001 |
|
RU2273638C2 |
| ENANTIOSELECTIVE SYNTHESIS OF 6-AMINO-7-HYDROXY-4,5,6,7-TETRAHYDROIMIDAZO[4,5,1-jk][1]BENZAZEPIN-2[1H]-ONE AND ZILPATEROL | 2008 |
|
RU2433131C2 |
| METHOD OF ENANTIOSELECTIVE HYDRATION OF AMINOALCOHOLS | 2003 |
|
RU2340594C2 |
| METHOD OF AMINE HYDROGENATION AND METHOD OF AMINE SYNTHESIS | 1995 |
|
RU2150464C1 |
| METHOD OF OBTAINING PROPIONIC ACID DERIVATIVES | 2010 |
|
RU2544989C2 |
| DERIVATIVES OF 2-OXO-1-PYRROLIDINE, METHODS FOR THEIR PREPARING AND USING | 2001 |
|
RU2292336C2 |
| CYCLOPEPTIDE DERIVATIVES | 1997 |
|
RU2202557C2 |
| METHOD FOR ASYMMETRICAL HYDROGENATION OF ACRYLIC ACID DERIVATIVES, CATALYSED BY TRANSITION METALS, AND NOVEL CATALYST SYSTEM FOR ASYMMETRICAL CATALYSIS WITH TRANSITION METALS | 2005 |
|
RU2415127C2 |
| METHOD OF STEREOSELECTIVE SYNTHESIS OF HETEROBICYCLIC ALCOHOL ENANTIOMER, INTERMEDIATE COMPOUNDS AND METHODS OF THEIR SYNTHESIS | 1997 |
|
RU2185379C2 |
| BENZAZEPIN, BENZOXAZEPIN OR BENZOTHIAZEPIN-N-ACETIC ACID, METHOD OF PREPARATION THEREOF, AND DRUG CONTAINED THEREIN | 1996 |
|
RU2159768C2 |
