INDOLE DERIVATIVES Russian patent published in 2005 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention relates to new derivatives of indole of the formula (I): wherein R¹ means phenyl substituted or unsubstituted radical R² and/or R⁴; R², R⁴ R⁵ and R⁶ in each case and independently of one another mean Hal; R³ mean substituted or unsubstituted radical R⁵ and/or R⁶ or means Het wherein Het means 2-furyl, 3-furyl, 2-thienyl or 3-thienyl; Hal means fluorine atom (F), chlorine atom (Cl), bromine atom (Br) or iodine atom (J), and their physiologically acceptable salts and solvates also. Compounds of the formula (I) are prepared by interaction of compound of the formula (I): wherein L means Cl, Br, J or free or reactive functional modified group OH; R³ has value indicated in the formula (I) with compound of the formula (III): . Compounds of the formula (I) show affinity to 5-HT_2A receptors that allow their using in the pharmaceutical composition.

EFFECT: valuable medicinal and pharmacological properties of compounds.

4 cl, 10 ex