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2 257 898

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IPC

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Application

2004108103/15, 2004-03-22

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Start date

2004-03-22

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Actual filing date

2004-03-22

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Published

2005-08-10

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Inventor

Baryshnikov A.Ju.Borisova L.M.Vorozhtsov G.N.Gerasimova G.K.Davydov M.I.Derkacheva V.M.Kokareva V.I.Kubasova I.Ju.Loshchenov V.B.Luzhkov Ju.M.Luk'Janets E.A.Meerovich G.A.Meerovich I.G.Oborotova N.A.Polozkova A.P.Smirnova Z.S.Stratonnikov A.A.

(73)

Holder

Federal'Noe Gosudarstvennoe Unitarnoe Predprijatie Nauchnyj Tsentr Institut Organicheskikh Poluproduktov I Krasitelej"Gosudarstvennoe Uchrezhdenie Rossijskij Onkologicheskij Nauchnyj Tsentr Im. N.N. Blokhina Rossijskoj Akademii Meditsinskikh Nauk Ronts Im. N.N. Blokhina Ramn)

PHOTOSENSIBILIZING AGENT, LIPOSOMAL FORMULATION OF PHOTOSENSIBILIZING AGENT AND METHOD FOR CARRYING OUT PHOTODYNAMIC THERAPY Russian patent published in 2005 - IPC

Abstract RU 2257898 C1

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to a photosensibilizing compound representing phenylthio-substituted derivative of phthalocyanine of the general formula (I): wherein R means hydrogen atom (H), t-C₄H₉; M means HH, AlOH, Zn. Also, invention relates to its liposomal formulation representing the composition of mixture of lipids (lecithin, cholesterol, cardiolipin) and a photosensibilizing agent, and to a method for carrying out the photodynamic therapy using this formulation. Photosensibilizing agents show high elimination rate from normal tissues, provide the deep therapeutic effect on tumor tissues, non-toxic properties and perspective for their using in oncology and other branches of medicine.

EFFECT: valuable medicinal properties of compound.

4 cl, 3 dwg, 9 ex

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RU 2 257 898 C1

Authors

Baryshnikov A.Ju.

Borisova L.M.

Vorozhtsov G.N.

Gerasimova G.K.

Davydov M.I.

Derkacheva V.M.

Kokareva V.I.

Kubasova I.Ju.

Loshchenov V.B.

Luzhkov Ju.M.

Luk'Janets E.A.

Meerovich G.A.

Meerovich I.G.

Oborotova N.A.

Polozkova A.P.

Smirnova Z.S.

Stratonnikov A.A.

Dates

2005-08-10—Published

2004-03-22—Filed