TETRAAZACHLORINES AS PHOTOSENSIBILIZATORS FOR PHOTODYNAMIC THERAPY Russian patent published in 2006 - IPC C07D487/22 C07F3/06 A61K31/40 

FIELD: organic chemistry, medicine, oncology.

SUBSTANCE: invention relates to photosensitizing agents used in photodynamic therapy of neoplasm and some other diseases. Invention describes tetraazachlorines of the general formula: wherein R₁R₂ mean -C₆H₄; R₃ = R₄ = R₅ mean -CH₃; M means HH (H₂TBTAC); R₁R₂ means 1,2-C₁₀H₆; R₃ = R₄ = R₅ mean -CH₃; M means Zn(Zn-1,2-TNTAC); R₁ = R₂ mean -C₆H₅; R₃ = R₄ = R₅ mean -CH₃; M means HH (H₂TACPh₆); R₁ = R₃ mean hydrogen atom (H); R₂ =R₄ mean -C₆H₅; R₅R₅ mean -CH₂N(CH₃)CH_2; M means HH (H₂PyrTACPh₄); R₁R₂ mean 4-C(CH₃)₃C₆H₃; R₃ = R₄ mean hydrogen atom (H); R₅R₅ mean -CH₂N(CH₃)CH₂; M means HH (H₂TB^tTACPyr^N-Me) used as photosensitizing agents in the near IR-region of spectrum for carrying out the photodynamic therapy. These photosensitizing agents possess the intensive absorption in spectral region 710-750 nm and can be used in treatment of deep tumor tissues by the photodynamic therapy method.

EFFECT: valuable medicinal properties of compounds.

1 cl, 4 ex