FIELD: organic chemistry, medicine.
SUBSTANCE: invention describes a method for preparing derivatives of benzoxazine and describes a method for preparing compound represented by the formula 
. Method involves of compound represented by the formula (I): 
with compound represented by the formula (II-1-a): 
in the presence of a base to form compound represented by the formula (III-1-a): 
followed by reduction of this compound to compound represented by the formula (IV-a): 
, interaction of this compound with compound represented by the following formula: 
to form compound represented by the formula (V-a): 
and the following treatment of this compound in the presence of a base to obtain compound represented by the formula (VI-a): 
, treatment of this compound with compound of boron trifluorine and its conversion by this manner to the boron chelate compound represented by the following formula: 
followed by reaction of this compound with 4-methylpiperazine to obtain compound represented by the following formula: 
followed by cleavage and elimination of boron chelate of this compound. In each of above given formulas X1, X2 and X3 represents independently halogen atom; R1 represents a leaving group; R3 represents hydrogen atom or carboxyl-protecting group; R4 represents hydroxyl-protecting group; each R5 and R6 represents independently alkyl group comprising 1-6 carbon atoms; R7 represents carboxyl-protecting group; Y represents alkoxy-group comprising 1-6 carbon atoms, halogen atom or dialkylamino-group (wherein alkyl groups can be similar or different and each represents alkyl group comprising 1-6 carbon atoms). Also, invention describes variants above described method, methods for preparing intermediate compounds and intermediate compound. Invention provides industrially favorable methods for preparing intermediate compounds that are useful for preparing compounds with antibacterial properties.
EFFECT: improved preparing methods, valuable properties of compounds.
96 cl, 102 ex
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