DERIVATIVES OF 8-PHENYL-6,9=DIHYDRO[1,24]TRIAZOLO[3,4-i]PURINE-5-ONE, METHODS FOR THEIR PREPARING, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND TREATMENT METHOD Russian patent published in 2005 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention describes derivatives of 8-phenyl-6,9-dihydro[1,2,4]-triazolo[3,4-I]purine-5-one of the general formula:

wherein R¹ means hydrogen atom, group -CH₂-R⁶ wherein R⁶ means phenyl; R² means (C₁-C₅)-alkyl or group -(CH₂)_n-R⁶ wherein n= 1 or 2; R⁶ means (C₁-C₄)-alkoxy-group or pyridyl group; R³ means (C₁-C₆)-alkyl; R⁴ means hydrogen atom or (C₁-C₄)-alkyl; R⁵ means -(CH₂)_n-R⁷ wherein n = 0-4; R⁷ means 3-7-membered ring comprising 1-3 heteroatoms taken among nitrogen atom (N) and oxygen atom (O), (C₃-C₇)-cycloalkyl or phenyl wherein indicated groups can be substituted with different substitutes; or R⁴ and R⁵ mean independently hydrogen atom (H), (C₂-C₆)-alkynyl or (C₁-C₆₎-alkyl that can be substituted possibly; or R⁴ and R⁵ in common with nitrogen atom (N) form 4-7-membered ring comprising 1-2 heteroatoms taken among N and O and substituted possibly. Also, invention relates to their pharmaceutically acceptable salts, methods for preparing these compounds, intermediate substances, pharmaceutical composition and a to a method for treatment of different diseases mediated by activity of phosphodiesterase-5 (PDE-5). Described compounds of the formula (I) are inhibitor of PDE-5.

EFFECT: improved preparing method and treatment, valuable properties of compounds.

20 cl, 5 tbl, 149 ex