STRAIN OF BACTERIUM ESCHERICHIA COLI PHMB DESIGNATED FOR PROTECTION OF FUR ANIMALS FROM TOXICOSIS CAUSED BY INTESTINAL MICROORGANISM ENTEROTOXINS AND CURATIVE-PROPHYLACTIC PREPARATION BASED ON THEREOF Russian patent published in 2005 - IPC

FIELD: biotechnology, veterinary science, microbiology.

SUBSTANCE: strain is prepared by fusion of E. coli genes isolated from mink intestine that induce biosynthesis of microcine C51 and B-subunit of escherichia thermolabile enterotoxin into the genome. Microcine inhibits growth and development of enterobacteria producing thermolabile, thermostable and shiga-like (verotoxin) enterotoxins, and B-subunit screens intestine receptors for enterotoxin and initiates specific immunity in intestine as far as intestine comprises determinants of protective antigen of toxin molecule. The strain is used for preparing curative-prophylactic preparations with prolonged action. Microcines synthesized by the strain inhibit enterotoxic enterobacteria and synthesized B-subunits of escherichia thermolabile enterotoxin screen receptors for enterotoxin and stimulate specific immunity in intestine. Resident properties of a carrier don't cause rejection of the strain by the mink intestine microecosystem that allows applying these preparations based on thereof more rarely and in smaller doses.

EFFECT: valuable properties of preparation.

2 cl, 4 ex