SUBSTITUTED DERIVATIVES OF 2-DIALKYLAMINOALKYLBIPHENYL Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine.

SUBSTANCE: invention reports about preparing new substituted derivatives of 2-dialkylaminoalkylbiphenyl of the general formula (I):

wherein n = 1 or 2; R¹ means cyano-group (CN), nitro-group (NO₂), SO₂CH₃, SO₂CF₃, NR^6aR^7a, acetyl or acetamidyl; R² means hydrogen atom (H), fluorine atom (F), chlorine atom (Cl), bromine atom (Br), cyano-group (CN), nitro-group (NO₂), CHO, SO₂CH₃, SO₂CF₃, OR⁶, NR⁶R⁷, (C₁-C₆)-alkyl, acetyl or acetamidyl being alkyl can comprise one or more similar or different substitutes taken among halogen atom or hydroxy-group; or R¹ and R mean in common group -OCH₂O, -OCH₂CH₂O, CH=CHO, CH=C(CH₃)O or CH=CHNH; R³ means H, F, Cl, Br, CN, NO₂, CHO, SO₂CH₃, SO₂CF₃, OR⁶, NR⁶R⁷, (C₁-C₆)-alkyl, acetyl or acetamidyl being alkyl can comprise one or more similar or different substitutes taken among halogen atom or hydroxy-group; R⁴ and R⁵ have similar or different values and mean hydrogen atom (H) or unsubstituted (C₁-C₆)-alkyl; R⁶ and R⁷ have similar or different values and mean hydrogen atom (H) or unsubstituted (C₁-C₆)-alkyl; R^6a means hydrogen atom (H) or unsubstituted (C₁-C₆)-alkyl; R^7a means unsubstituted (C₁-C₆)-alkyl as their bases and/or salts of physiologically acceptable acids, with exception of compound representing 4-chloro-2'-dimethylaminomethylbiphenyl-2-carbonitrile and to a method for their preparing. Derivatives of 2-dialkylaminoalkylbiphenyl can be used in medicine for treatment or prophylaxis of pains, inflammatory and allergic responses, depressions, narcomania, alcoholism, gastritis, diarrhea, enuresis, cardiovascular diseases, respiratory ways diseases, cough, psychiatry disorders and/or epilepsy.

EFFECT: valuable medicinal properties of compounds.

13 cl, 2 tbl, 43 ex