METHOD FOR PREPARING (+)-GLAUCINE HYDROCHLORIDE (VARIANTS) Russian patent published in 2005 - IPC

FIELD: pharmaceutical technology.

SUBSTANCE: method involves extraction of the above-ground part of yellow poppy (Glaucium flavum Crantz.) with an organic solvent, the following filtration, alkalization of an aqueous-acid solution, extraction of alkaloids with an organic solvent, removing an organic solvent under vacuum, treatment of prepared glaucine base with hydrochloric acid and purifying the product. Extraction of vegetable raw is carried out with 60% aqueous alcohol solution in the presence or tribasic mineral acid, for example, phosphoric acid. Organic solvent is removed under vacuum, an aqueous vat residue is neutralized with mixture of calcium carbonate and calcium chloride, or calcium carbonate and aluminum chloride followed by filtration. Filtrate is alkalinized to obtain alkaloid bases that are extracted from an aqueous phase with an organic solvent, preferably, with aromatic solvent, for example, with benzene or toluene. Organic phase is evaporated under vacuum, residue is treated with hydrochloric acid and product is subjected for purification, or after filtration alkaloid hydrochlorides formed are extracted with chloroform. Organic phase is evaporated under vacuum and product is subjected for purification. Invention provides simplifying the process.

EFFECT: improved preparing method.

2 cl, 5 ex