FIELD: biotechnology, medicine industry.
SUBSTANCE: Alkaloid agroclavine is produced by coltivation of fungi Claviceps sp. c106 under aeration conditions and with agitation in aqueous broth containing sucrose, citric acid, yeast extract and mineral salts. Additionally broth contains 1.0-20.0 mol of tryptophan. Medium pH is adjusted with 25 % solution of NH4OH to 4.5-5.4. Target product is isolated from culture liquid by conventional methods.
EFFECT: increased content of agroclavine in culture liquid and in alkaloid mixture.
10 ex
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0 |
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Authors
Dates
2005-09-10—Published
2003-04-08—Filed