LIGANDS OF THYROID RECEPTORS: DERIVATIVES OF ANILINE Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to preparing new ligands of thyroid receptors of the general formula: wherein X means oxygen (-O-); Y means -(CH₂)_n-; n means a whole number from 1 to 3; or -C=C- that represents cis- or trans-isomer. R₁ means alkyl comprising 3-6 carbon atoms; R₂ and R₃ are similar or distinct and mean hydrogen, halogen atom, alkyl comprising 1-4 carbon atoms wherein at least one of R₂ and R₃ doesn't mean hydrogen atom; R₄ means hydrogen atom or lower alkyl; R₅ means hydrogen atom; R₆ means carboxylic acid or its ester; R₇ means hydrogen atom and including its all stereoisomers or its pharmaceutically acceptable salt. New compounds can be useful for prophylaxis, suppression or treatment of disease caused by the metabolism dysfunction or the expression of T₃-regulated gene, for example, such diseases as obesity, hypercholesterolemia, atherosclerosis, cardiac arrhythmia, depression, osteoporosis, hypothyroidism, goiter, thyroid gland cancer, glaucoma, congestive cardiac insufficiency and skin injures.

EFFECT: valuable medicinal properties of ligands.

19 cl, 1 tbl, 19 ex