DERIVATIVES OF BENZAMIDE OR PHENYLACETAMIDE USEFUL AS THYROID RECEPTOR Russian patent published in 2008 - IPC C07C235/52 C07C235/34 A61K31/195 A61P5/16 

FIELD: organic chemistry, medicine, endocrinology, pharmacy.

SUBSTANCE: invention relates to derivatives of benzamide or phenylacetamide that are ligands of thyroid receptors, and to methods for synthesis of these compounds. Except for, invention claims a pharmaceutical composition possessing activity with respect to thyroid hormone receptor and comprising the effective amount of the claimed compound or its pharmaceutically effective salt in combination with a pharmaceutically acceptable carrier, and a method for its preparing. Also, invention claims a method for prophylaxis, inhibition or treatment of disease depending on expression of T₃-regulated gene or associated with metabolism disorder, and this method involves administration of the therapeutically effective dose of the claimed compound in a patient needing for such treatment. The aim of invention involves using a compound for preparing a medicinal agent used for inhibition or treatment of disease that depends on expression of T₃-regulated gene or associated with disorder of metabolism.

EFFECT: valuable medicinal properties of compound.

12 cl, 7 sch, 14 ex