METHOD FOR LYOPHILIC DRYING OF BIOLOGICAL PREPARATION Russian patent published in 2005 - IPC

FIELD: methods for producing of dried biological preparations.

SUBSTANCE: method involves introducing, before drying process, into biological preparation a solution of filler, followed by freezing and holding of resultant mixture at freezing temperature; drying said mixture. Biological preparation used is solution of hydrolyzate of sea hydrobionts selected from the group comprising mussel hydrolyzate, hydrolyzate of rapine flesh, hydrolyzate of salmon fish milt, hydrolyzate of deep-sea scallop, or hydrolyzate of squid gonad, with salt content of from 10% to 15%. Filler is neutral polysaccharide selected from the group comprising starch or methyl cellulose, used in an amount of 5-40% by weight of hydrolyzate of sea hydrobionts. Method further involves mixing resultant mixture and pouring into containers, with layer height being 8-10 mm; freezing at temperature of -40°C to -45°C and holding at said temperatures for 4-10 hours; drying until dry substance content is 90-94%; grinding preparation after drying. Preparation may be supplied in the form of capsules and tablets.

EFFECT: increased efficiency in freezing-through of mixture during freezing process owing to introducing of neutral polysaccharide, stabilized drying process owing to selected drying process parameters and prolonged shelf life of biological preparation.

5 cl, 6 ex